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Year : 2023  |  Volume : 23  |  Issue : 1  |  Page : 10-16

A review of interferential therapy application in sport physical therapy

1 Department of Physical Therapy, King Abdulaziz Hospital, Makkah, Saudi Arabia
2 Department of Public Health, Healthcare Cluster, Makkah, Saudi Arabia

Date of Submission10-Apr-2023
Date of Decision20-May-2023
Date of Acceptance21-May-2023
Date of Web Publication07-Aug-2023

Correspondence Address:
Ahmad Khiyami
Department of Physical Therapy, King Abdulaziz Hospital, Makkah
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjsm.sjsm_4_23

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Interferential therapy (IFT) is considered to be the most commonly used electrical modality in the management of different cases in the physiotherapy clinic. IFT use of therapeutic frequencies involves the combination of two-medium level frequencies that penetrate deeply through the skin and muscle to the acupuncture point, without causing pain to the patients. In addition, it has many advantages as it is considered safe, easy to use, nonpharmacological, noninvasive, and effective in terms of rehabilitation. It is also effective in most musculoskeletal disorders as well as in sports injuries such as muscle, joint, ligament, tendon, and bone injuries. IFT has five main approaches relating to its effect on pain, muscle stimulation, vasodilatation, edemas, and bone healing. All of these approaches require different frequencies, intensities, and patterns in order to achieve the anticipated outcome. In conclusion, IFT is effective and easy to apply, and many researchers recommend that it should be considered an option in terms of rehabilitation and sports management.

Keywords: Interferential therapy, rehabilitation, sport physical therapy, sports injuries

How to cite this article:
Khiyami A, Almalki RS, Khayame N. A review of interferential therapy application in sport physical therapy. Saudi J Sports Med 2023;23:10-6

How to cite this URL:
Khiyami A, Almalki RS, Khayame N. A review of interferential therapy application in sport physical therapy. Saudi J Sports Med [serial online] 2023 [cited 2023 Sep 22];23:10-6. Available from: https://www.sjosm.org/text.asp?2023/23/1/10/383098

  Introduction and Theory of Interferential Therapy Top

Interferential therapy (IFT) or interferential current (IFC) is a form of transcutaneous electrical stimulation that uses medium-frequency electrical current. It is a commonly used physical therapy treatment modality used for different forms of therapeutic management and rehabilitation. IFT is a safe therapeutic option for the management of different musculoskeletal disorders. In addition, it has few side effects as a result of being a nonpharmacological and noninvasive form of treatment.[1],[2],[3],[4],[5],[6] Many portable IFT operators have become readily available recently with many magnitudes. These are good for delivering the correct therapeutic IFT current, though some devices have inadequate implementation and ability.[7]

As far as therapeutic effects are concerned, on the one hand, the electrical current has to penetrate deeply through the musculature and skin.[8] The resistance caused by the musculature and skin could be painful for the patient and could reduce the current flow which reduces the anticipated effect.[7],[9] Consequently, a higher frequency current might be required to achieve the predicted outcomes.[7],[9],[10] On the other hand, low-frequency currents result in high skin resistance. In contrast, high-frequency currents result in low skin resistance and pass through the musculature and skin without pain.[10]

However, high- and low-interferential frequency currents are not suitable with regard to stimulating nerves. For that reason, in the 1950s, an Austrian physicist called Nemec developed the IFC by crossing and combining two different medium-frequency waves (4000 and 4100 Hz) to produce a new therapeutic-frequency current known as amplitude modulation effects of 0–250 Hz. These produce lower skin resistance and allow deeper penetration into the skin and muscles.[8],[11],[12],[13] This new combined current is supposed to be produced at the site of the bisection of the two diagonally opposed currents as a result of their interference with each other.[3],[14]

The uses of IFT include enhancing muscle strength and endurance by continuing contraction through the muscles, controlling and reducing pain by pain gate theory and pain mechanism,[15],[16] as well as enhancing tissue healing, managing spasticity, reducing joint swelling, improving the range of motion of joints, and assisting in the use of orthoses.[16],[17],[18],[19],[20],[21] IFT has many advantages including being completely noninvasive, easy to use, cost-effective, and suitable for wide use as it can be self-administered at home.[22] Notable that the main cons of therapeutic interferential are to be considered the placebo effect in many studies in terms of pain which may give false and inaccurate indications.[23],[24]

  Interferential Application Top

There are many IFT application methods, including bipolar (one channel/two electrodes), quad polar (two channels/four electrodes), and the stereodynamic method (three-dimensional).[7],[9] Studies have shown that the bipolar technique may be clinically more effective than the traditional true IFC arrangement (quad polar) in terms of torque production, depth effectiveness, and comfort on the part of the patient,[10] while quad polar is more effective in terms of pain.[7] Moreover, there are five types of frequency sweep: first, constant frequency (1–100 Hz) which produces an analgesic effect conducting with sensory nerve ending to relieve pain, and fine vibrations of ions without a heating effect. Second, rhythmic frequency (1–100 Hz) can produce relaxation in the tissue with hyperemia and increase circulation activity caused by stimulating fine vibrations in the ions that are commonly needed to facilitate the healing process and relieve edema. Third, constant frequency (1–10 Hz) causes muscle contractions as a result of motor nerve facilitating. Fourth, rhythmic frequency (1–10 Hz), which stimulates the motor nerve and causes a vasodilatory effect that facilitates the absorption of exudates. Fifth, rhythmic frequency (90–100 Hz) causes analgesic and vasodilatory effects on tissue and it is commonly used for neuralgic types of pain.[7] The frequency sweep pattern includes triangular, rectangular, and trapezoidal. It is worth noting that the frequency pattern makes a significant difference to the stimulation received by the patient.[7],[9]

IFT has three types of electrodes: (1) plate electrodes which are made of rubber in order to be more comfortable for the patient. A therapist can achieve a deeper penetration by using a large electrode and a superficial one by using a small electrode. (2) Vacuum electrodes which consist of a rubber suction cup. The aim of using vacuum electrodes type is to provide good contact to flat, smooth areas such as the back and plump knees. (3) Combined electrodes which can be applied at the same time in different areas of the body and contain different sizes such as small, medium, and large.[9],[25],[26]

  Interferential Parameter and Frequency of Treatment Top

It had been recommended that IFT should be applied three times per week for 12 weeks (depending on the severity and phase of the injuries) in order to achieve the desired outcome. The intensity of the current should be firm but comfortable to the patients, leading to the tingling sensation, without or with a contraction of the muscles. The duration should be 10–15 min, but no longer than 20 min in the same area. In the event of many areas needing treatment, the overall application should not exceed 30 min.[17],[26],[27],[28],[29]

  Interferential Clinical Application in Sports Management Top

Studies have shown that there are five main IFT approaches that can be used in sports management. These relate to the effect on pain, muscle stimulation, vasodilatation, edemas, and tissue healing. All of these require different frequencies and intensities in order to achieve the desired outcome. These approaches should be considered carefully as part of the management process.[7],[9]

Effect on pain (pain gait theory)

Many studies have shown that IFT should be considered principally for use in the control of pain which markedly reduces the pain.[9],[30] IFT is commonly used clinically in terms of reducing pain in the form of an analgesic effect.[18],[31],[32],[33],[34],[35] The sedative effect of therapeutic IFT involves increasing local vasodilatory on the tissues and the pain gait theory[15] which can be explained as the following. When action potential traveling through large diameter myelinated afferent nerves to the central ascending sensory tracts in the dorsal horn of the spinal cord with small diameter unmyelinated sensory fibers carrying pain information. At a constant frequency of 100 Hz, large-diameter myelinated fibers are stimulated optimally leading to closing the pain gate and reducing the pain markedly.

It has been clinically shown that pain will be reduced at IFT frequencies (90–130 Hz), particularly when applied to acupuncture points. Pain will also diminish as a result of surges in terms of the circulation of body fluid which encourages the efflux of pain-inducing chemicals from the site of any damage.[9],[17],[26],[36],[37],[38],[39]

Furthermore, pain can be diminished by blocking C fiber transmission at >50 Hz.[7] It should be considered that IFT is not effective in posttraumatic phase (acute phase) but highly effective in the chronic phase with or without swelling. One experiment had done on male Wistar rats, approved that IFT can be effective in acute inflammatory pain and acute edema reduction but on the human still questionable.[5],[40]

Muscle stimulation effect

Nerve stimulation can be achieved at a low frequency (1–10 Hz). Such a frequency will lead to a sequence of twitches, while 50 Hz leads to a tetanic contraction. Notably, there is inadequate significant evidence regarding the strengthening effect of the therapeutic interferential unit.[9],[13] However, many researchers have illustrated that such a strengthening may be possible at an 80 Hz frequency.[41],[42] IFT is beneficial when it comes to generating useful voluntary contractions and activating the muscles after injury but may not be effective when it comes to strengthening exercises.[43] Bellew et al.[21] studied the stimulation effects of IFT in terms of the capacity to produce significant muscle contraction. The results showed that IFT could be considered a treatment choice.

The selection of the treatment parameters depends on the anticipated effects. The actual stimulation range of the motor nerve when using IFT appears to be between 10 and 20 Hz or 10 and 25 Hz. Stimulation lower than 10 Hz results in a sequence of twitches which can be clinically beneficial. However, the use of IFT has yet to be unambiguously demonstrated. Stimulation at higher frequencies such as 20 or 25 Hz can generate a robust tetanic contraction, which can be helpful to identify which muscle requires straightening.[9],[27],[44] Many studies have shown that IFT can generate muscle torque and activation and reduce muscle fatigue.[39],[45] Many researchers recommend that an exercise regime should be associated with IFT in order to produce clinical levels of muscle contraction in the muscle under treatment. It is possible to continuously stimulate the muscle beyond the fatigue point because the motor nerve forces contractions. In addition, short stimulation periods with adequate rest can be beneficial. Many IFT operators are capable of producing a surged stimulation mode which can be beneficial in reducing fatigue markedly.[7],[9],[13]

Increased local blood flow

Many experiments had shown that therapeutic interferential can increase blood flow in the targeting area, especially on the superficial parts such as skin and fascia.[7],[8],[46] Deep effect of IFT on blood flow is still questionable. Noble et al.[28] illustrated that the vascular changes at 10–20 Hz showed a significant increase in vascular blood flow. The mechanism of increasing blood flow is due to continuous contraction in the muscle as the effect of therapeutic interferential at 10–20 Hz, which increases the metabolic enzymes. Some evidence showed that the mechanism occurs due to an inhibitor or sympathetic activity, but it is still a theoretical possibility. However, based on the currently existing evidence, the most likely possible explanation for increasing local blood is continuous contraction in the muscle which increases the metabolic enzymes (10–20 or 10–25 Hz frequency sweep).[7]

Edema and tissue healing process

IFT could be used to reduce edemas and joint effusion as a result of muscle contraction and could increase the metabolic changes which encourage the reabsorption of tissue fluid as a result of vasodilatation and rising cell membrane permeability which helps ions movement to and from cells.[40],[47] The most useful frequencies that are used in edema reduction are 1–30 Hz causing electroporation and 1–10 Hz causing vasodilation effect.[7] Studies have shown that using a suction electrode may be beneficial in reducing edema, but the evidence remains limited.[9],[34] Jarit et al.[18] illustrated a change in edema following knee surgery among 87 patients who had different forms of knee surgery such as anterior cruciate ligament repair, meniscectomy, or chondroplasty. The subjects were allocated into three groups and given IFT for 9 weeks. The results showed a significant postoperative reduction in edema by week 4 as measured by circumferential knee tape. Other studies showed a significant reduction in edema size following IFT.[17],[48] IFT can promote and accelerate the tissue healing process including bone, nerve, tendon, and ligament repair by increasing the number of metabolic enzymes including monophosphate, acetylcholine esterase, phosphatase, and lysosomal enzymes which lead to new cell formation in the damaged area.[7],[9],[49],[50]

These five approaches can be used in the management of different sports injuries such as muscle spasm, strain, contusion, hematoma, tendinopathy, and ligamentous lesion as a result of reducing pain, increasing cell formation, reducing edema, and improving functional velocity.[32],[51],[52] Additionally, joint injuries such as arthritis pain can be managed as a result of improved joint functions and increased blood flow.[18],[33],[53],[54],[55] Furthermore, joint edema can be reduced by muscle contraction and improved edema absorption.[7],[9],[34],[41],[44],[54],[56] Moreover, IFT can be beneficial in the management of nonspecific low back pain in terms of pain level, function, and quality of life, as a result of enhancing muscle activity and reducing muscle spasms.[12],[16],[57],[58],[59],[60],[61],[62]

Nazligul et al.[63] reported that IFT could be useful in shoulder disorder management by reducing pain, improving the tissue healing process, and normalizing tissue around the joint. Furthermore, Cheing et al.[64] and Gaba et al.[65] showed that a frozen shoulder could be treated by IFT. Moreover, Taskaynatan et al.[66] illustrated that IFT is effective in cases of bicipital tendonitis by relieving pain and enhancing tendon function. Furthermore, IFT is considered to be effective in terms of musculoskeletal disorder management.[1],[9],[17],[18],[19],[57]

Moreover, it has been demonstrated that IFT can be beneficial in the management of carpal tunnel syndrome,[67] fibromyalgia,[38] accelerating pressure ulcer healing and decreasing ulcer size,[68] treating sports hernia,[56] chronic wound healing as a result of the stimulating effect.[69],[70],[71] It has been reported that IFT can be beneficial in rising mechanical pain threshold after eccentric exercise which can delay muscle soreness.[72] Jarit et al.[18] illustrated that the use of IFT may enhance rehabilitation after sports injuries which may accelerate the return to athletic activities.

  Application of Interferential Therapy in Sports Injury Rehabilitation Phases Top

Different classifications regarding sports injury rehabilitation phases had been described in the literature. However, there is agreement that the phases of sports injury rehabilitation consist of four phases.[73] Phase 1 (acute phase) focuses on reducing pain, swelling, inflammation, and promoting tissue healing. Phase 2 consists of flexibility and restoring range of motion. Treatment may include exercises that are specific to the injured area, as well as electrotherapy modalities to facilitate healing. Phase 3 includes improving strength, agility, balance, and endurance. Phase 4 involves the resumption of sports training and performance. This phase aims to return the athlete to full function and prepare them for sport-specific activities. This phase aims to return the athlete to full function and prepare them for sport specific activities and a gradual return to competition, along with support to prevent re injury.[73],[74]

The application of IFT during these rehabilitation phases may improve and accelerate the return to sports and prevent recurrent injuries. It should be considered that IFT is not effective in the posttraumatic phase (phase 1), but it is highly effective in the chronic phase with or without swelling.[5],[40] IFT can be applied during the subacute phase (phases 2 and 3) to improve circulation and encourage healing of injured tissues as a result of an increase in metabolic enzymes.[7],[28] During the return-to-sport phase (phase 4), IFT can be utilized to help the athlete in recovering strength and flexibility in the injured area.[21],[43] It can also be used to prevent future injuries by improving circulation and promoting tissue healing.[7],[46]

  Other Clinical Applications Top

IFT can be used in treating many other cases such as gastrointestinal dysfunction and stress incontinence.[9],[22],[42],[49],[75],[76] Moreover, a study involved 43 patients who were diagnosed with dysphagia. The results show that using IFT through the neck can enhance airway protection and nutrition in patients who have dysphagia as a result of enhancing saliva production.[77],[78] Furthermore, reducing knee arthritis pain,[16],[79],[80] improving knee functions,[32],[33],[53],[54],[55] and chronic neck pain.[81]

  Contraindications and Precautions Top

There are several contraindications with regard to IFT that should be considered during rehabilitation by either the therapist or the patient. These include arterial disease, deep vein thrombosis, infectious conditions, pregnancy, hemorrhagic patients, malignant tumors, artificial pacemakers, open wounds, and dermatological conditions. Furthermore, many contraindications among athletes should be considered that including sensitive or irritable skin, open wound injuries, after training (due to high circulation and heart rate).[28],[55]

In addition, interferential precautions must be considered which include abnormal skin sensation, patients with abnormal circulation and cardiac diseases, patients with febrile conditions, patients who have epilepsy, and electrode placement over the chest area.[7],[9],[13] Satter[82] and ten Duis[83] reported that therapeutic interferential could lead to an electrical burn. Furthermore, Keramat and Gaughran[84] illustrated that IFT might interfere with the effect of drugs such as tramadol.

  Conclusion Top

IFT is considered to be the most commonly used electrical modality in the management of a variety of cases in physiotherapy clinics. The use of therapeutic frequencies in IFT involves combining two medium-level frequencies that penetrate deeply through the skin and muscle to reach the acupuncture point without causing pain to the patient. In addition, IFT has many advantages as it is considered safe, nonpharmacological, noninvasive, and effective in rehabilitation. IFT has four main approaches that can be used in sports management, including pain relief, muscle stimulation, edema reduction, tissue healing promotion, and blood flow increase. All of these require different electrical frequencies and intensities in order to achieve the desired outcome. IFT is effective in treating a wide range of musculoskeletal disorders, including sports injuries such as muscle strains, spasms, and contusions. Moreover, it can be beneficial in many other disorders, such as dysphagia, gastrointestinal dysfunction, incontinence, low back pain, chronic knee osteoarthritis, and wound management, and accelerate the ulcer healing process. The precautions and contraindications with regard to IFT should be taken into consideration during rehabilitation by either the therapist or the patient.


Special thanks to the Saudi Ministry of Health for giving us all the resources that we needed and supporting us.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Shah SG, Farrow A, Esnouf A. Availability and use of electrotherapy devices: A survey. Int J Ther Rehabil 2007;14:260-4.  Back to cited text no. 1
Facci LM, Nowotny JP, Tormem F, Trevisani VF. Effects of transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) in patients with nonspecific chronic low back pain: Randomized clinical trial. Sao Paulo Med J 2011;129:206-16.  Back to cited text no. 2
Palmer ST, Martin DJ, Steedman WM, Ravey J. Alteration of interferential current and transcutaneous electrical nerve stimulation frequency: Effects on nerve excitation. Arch Phys Med Rehabil 1999;80:1065-71.  Back to cited text no. 3
Agharezaee M, Mahnam A. A computational study to evaluate the activation pattern of nerve fibers in response to interferential currents stimulation. Med Biol Eng Comput 2015;53:713-20.  Back to cited text no. 4
Jorge S, Parada CA, Ferreira SH, Tambeli CH. Interferential therapy produces antinociception during application in various models of inflammatory pain. Phys Ther 2006;86:800-8.  Back to cited text no. 5
Lee HE, Park K. Efficacy of salvage interferential electrical stimulation therapy in patients with medication-refractory enuresis: A pilot study. Int Neurourol J 2013;17:139-44.  Back to cited text no. 6
Watson, T. Interferential Therapy (IFT); 2017. Available from: http://www.electrotherapy.org/modality/interferential-therapy. [Last accessed on 2018 Nov 20].  Back to cited text no. 7
Petrofsky J. The effect of the subcutaneous fat on the transfer of current through skin and into muscle. Med Eng Phys 2008;30:1168-76.  Back to cited text no. 8
Goats GC. Interferential current therapy. Br J Sports Med 1990;24:87-92.  Back to cited text no. 9
Ozcan J, Ward AR, Robertson VJ. A comparison of true and premodulated interferential currents. Arch Phys Med Rehabil 2004;85:409-15.  Back to cited text no. 10
DE Domenico G. Pain relief with interferential therapy. Aust J Physiother 1982;28:14-8.  Back to cited text no. 11
Lara-Palomo IC. Short-term effects of interferential current electro-massage in adults with chronic non-specific low back pain: A randomized controlled trial. Clin Rehabil 2013;27:439-49.  Back to cited text no. 12
Low J. Electrotherapy Explained: Principles and Practice. Oxford: Butterworth-Heinemann; 1990.  Back to cited text no. 13
Beatti A, Rayner A, Chipchase L, Souvlis T. Penetration and spread of interferential current in cutaneous, subcutaneous and muscle tissues. Physiotherapy 2011;97:319-26.  Back to cited text no. 14
Melzack R, Wall PD. Pain mechanisms: A new theory. Science 1965;150:971-9.  Back to cited text no. 15
Sayed T, Dalia K, Walid K, Gopal N. A randomized controlled trial investigating the impact of interferential therapy on pain, range of motion and quality of life in patients with chronic non-specific low back pain. Arch Balkan Medical Union 2020;55:47-51.  Back to cited text no. 16
Kitchen S. Electrotherapy explained – Principles and practice. Physiotherapy 1996;82:302.  Back to cited text no. 17
Jarit GJ, Mohr KJ, Waller R, Glousman RE. The effects of home interferential therapy on post-operative pain, edema, and range of motion of the knee. Clin J Sport Med 2003;13:16-20.  Back to cited text no. 18
Franco YR, Liebano RE, Moura KF, de Oliveira NT, Miyamoto GC, Santos MO, et al. Efficacy of the addition of interferential current to Pilates method in patients with low back pain: A protocol of a randomized controlled trial. BMC Musculoskelet Disord 2014;15:420.  Back to cited text no. 19
Petrofsky J, Laymon M, Prowse M, Gunda S, Batt J. The transfer of current through skin and muscle during electrical stimulation with sine, square, Russian and interferential waveforms. J Med Eng Technol 2009;33:170-81.  Back to cited text no. 20
Bellew JW, Beiswanger Z, Freeman E, Gaerte C, Trafton J. Interferential and burst-modulated biphasic pulsed currents yield greater muscular force than Russian current. Physiother Theory Pract 2012;28:384-90.  Back to cited text no. 21
Moore JS, Gibson PR, Burgell RE. Neuromodulation via interferential electrical stimulation as a novel therapy in gastrointestinal motility disorders. J Neurogastroenterol Motil 2018;24:19-29.  Back to cited text no. 22
Mendonça Araújo F, Alves Menezes M, Martins de Araújo A, Abner Dos Santos Sousa T, Vasconcelos Lima L, Ádan Nunes Carvalho E, et al. Validation of a new placebo interferential current method: A new placebo method of electrostimulation. Pain Med 2017;18:86-94.  Back to cited text no. 23
Johnson MI, Tabasam G. A single-blind placebo-controlled investigation into the analgesic effects of interferential currents on experimentally induced Ischaemic pain in healthy subjects. Clin Physiol Funct Imaging 2002;22:187-96.  Back to cited text no. 24
Van Der Heijden GJ, Leffers P, Wolters PJ, Verheijden JJ, van Mameren H, Houben JP, et al. No effect of bipolar interferential electrotherapy and pulsed ultrasound for soft tissue shoulder disorders: A randomised controlled trial. Ann Rheum Dis 1999;58:530-40.  Back to cited text no. 25
Hurley DA, Minder PM, McDonough SM, Walsh DM, Moore AP, Baxter DG. Interferential therapy electrode placement technique in acute low back pain: A preliminary investigation. Arch Phys Med Rehabil 2001;82:485-93.  Back to cited text no. 26
Watson T. The role of electrotherapy in contemporary physiotherapy practice. Man Ther 2000;5:132-41.  Back to cited text no. 27
Noble JG, Henderson G, Cramp AF, Walsh DM, Lowe AS. The effect of interferential therapy upon cutaneous blood flow in humans. Clin Physiol 2000;20:2-7.  Back to cited text no. 28
Minder PM, Noble JG, Alves-Guerreiro J, Hill ID, Lowe AS, Walsh DM, et al. Interferential therapy: Lack of effect upon experimentally induced delayed onset muscle soreness. Clin Physiol Funct Imaging 2002;22:339-47.  Back to cited text no. 29
Venancio RC, Pelegrini S, Gomes DQ, Nakano EY, Liebano RE. Effects of carrier frequency of interferential current on pressure pain threshold and sensory comfort in humans. Arch Phys Med Rehabil 2013;94:95-102.  Back to cited text no. 30
Werners R, Pynsent PB, Bulstrode CJ. Randomized trial comparing interferential therapy with motorized lumbar traction and massage in the management of low back pain in a primary care setting. Spine (Phila Pa 1976) 1999;24:1579-84.  Back to cited text no. 31
Almeida CC, Silva VZ, Júnior GC, Liebano RE, Durigan JLQ. Transcutaneous electrical nerve stimulation and interferential current demonstrate similar effects in relieving acute and chronic pain: A systematic review with meta-analysis. Braz J Phys Ther 2018;22:347-54.  Back to cited text no. 32
Burch FX, Tarro JN, Greenberg JJ, Carroll WJ. Evaluating the benefits of patterned stimulation in the treatment of osteoarthritis of the knee: A multi-center, randomized, single-blind, controlled study with an independent masked evaluator. Osteoarthritis Cartilage 2008;16:865-72.  Back to cited text no. 33
Eftekharsadat B, Babaei-Ghazani A, Habibzadeh A, Kolahi B. Efficacy of action potential simulation and interferential therapy in the rehabilitation of patients with knee osteoarthritis. Ther Adv Musculoskelet Dis 2015;7:67-75.  Back to cited text no. 34
Walker UA, Uhl M, Weiner SM, Warnatz K, Lange-Nolde A, Dertinger H, et al. Analgesic and disease modifying effects of interferential current in psoriatic arthritis. Rheumatol Int 2006;26:904-7.  Back to cited text no. 35
Lara-Palomo IC, Aguilar-Ferrándiz ME, Matarán-Peñarrocha GA, Saavedra-Hernández M, Granero-Molina J, Fernández-Sola C, et al. Short-term effects of interferential current electro-massage in adults with chronic non-specific low back pain: A randomized controlled trial. Clin Rehabil 2013;27:439-49.  Back to cited text no. 36
Hurley DA, McDonough SM, Dempster M, Moore AP, Baxter GD. A randomized clinical trial of manipulative therapy and interferential therapy for acute low back pain. Spine (Phila Pa 1976) 2004;29:2207-16.  Back to cited text no. 37
Almeida TF, Roizenblatt S, Benedito-Silva AA, Tufik S. The effect of combined therapy (ultrasound and interferential current) on pain and sleep in fibromyalgia. Pain 2003;104:665-72.  Back to cited text no. 38
Youn JI, Lee HS, Lee S. Determination of effective treatment duration of interferential current therapy using electromyography. J Phys Ther Sci 2016;28:2400-3.  Back to cited text no. 39
Abdo SM, Nashed AB, Hasanin ME, Yassin RE. Effect of interferential current therapy versus cryotherapy on knee pain in osteoporotic postmenopausal women: a single-blind randomized controlled trial. Physiotherapy Quarterly 2020;28:30-4.  Back to cited text no. 40
Bircan C, Senocak O, Peker O, Kaya A, Tamci SA, Gulbahar S, et al. Efficacy of two forms of electrical stimulation in increasing quadriceps strength: A randomized controlled trial. Clin Rehabil 2002;16:194-9.  Back to cited text no. 41
Furuta T, Takemura M, Tsujita J, Oku Y. Interferential electric stimulation applied to the neck increases swallowing frequency. Dysphagia 2012;27:94-100.  Back to cited text no. 42
Verayunia SS, Wulan SM, Handajani NI, Kusumawardani MK, Darma A, Ranuh RG, et al. Improved abdomen muscle activity with interferential current therapy in cerebral palsy with constipation: a randomized controlled trial study. Bali Medical J 2023;12:64-8.  Back to cited text no. 43
Bounyong S, Adachi S, Yoshimoto T, Ota T, Ozawa J. Controlling interfered area in interferential current stimulation by electrode-area patterning. Annu Int Conf IEEE Eng Med Biol Soc 2016;2016:1721-4.  Back to cited text no. 44
da Silva VZ, Durigan JL, Arena R, de Noronha M, Gurney B, Cipriano G Jr. Current evidence demonstrates similar effects of kilohertz-frequency and low-frequency current on quadriceps evoked torque and discomfort in healthy individuals: A systematic review with meta-analysis. Physiother Theory Pract 2015;31:533-9.  Back to cited text no. 45
Petrofsky JS, Suh HJ, Gunda S, Prowse M, Batt J. Interrelationships between body fat and skin blood flow and the current required for electrical stimulation of human muscle. Med Eng Phys 2008;30:931-6.  Back to cited text no. 46
Shah N, Sheth M. Role of interferential therapy in osteoarthritis knee-a narrative review. J Evid Based Physiother Res 2017;1:12-6.  Back to cited text no. 47
Mendel FC, Fish DR. New perspectives in edema control via electrical stimulation. J Athl Train 1993;28:63-74.  Back to cited text no. 48
Fourie JA, Bowerbank P. Stimulation of bone healing in new fractures of the tibial shaft using interferential currents. Physiother Res Int 1997;2:255-68.  Back to cited text no. 49
Ganne JM. Stimulation of bone healing with interferential therapy. Aust J Physiother 1988;34:9-20.  Back to cited text no. 50
Nelson B. Interferential therapy. Aust J Physiother 1981;27:53-6.  Back to cited text no. 51
Sankar SR, Reddy BV. Effects of ultrasound therapy, interferential therapy, and combination of ultrasound therapy with interferential therapy on both anterior cruciate ligament injury (sprain) and bursitis of knee in sports. Int Conference on Enhancing Skills in Physical Education and Sport Sci 2020:144-9.  Back to cited text no. 52
Atamaz F, Kirazli Y, Akkoc Y. A comparison of two different intra-articular hyaluronan drugs and physical therapy in the management of knee osteoarthritis. Rheumatol Int 2006;26:873-8.  Back to cited text no. 53
Zeng C, Li H, Yang T, Deng ZH, Yang Y, Zhang Y, et al. Electrical stimulation for pain relief in knee osteoarthritis: Systematic review and network meta-analysis. Osteoarthritis Cartilage 2015;23:189-202.  Back to cited text no. 54
Fuentes JP, Armijo Olivo S, Magee DJ, Gross DP. Effectiveness of interferential current therapy in the management of musculoskeletal pain: A systematic review and meta-analysis. Phys Ther 2010;90:1219-38.  Back to cited text no. 55
Woodward JS, Parker A, Macdonald RM. Non-surgical treatment of a professional hockey player with the signs and symptoms of sports hernia: A case report. Int J Sports Phys Ther 2012;7:85-100.  Back to cited text no. 56
Bae YH, Lee SM. Analgesic effects of transcutaneous electrical nerve stimulation and interferential current on experimental ischemic pain models: Frequencies of 50 hz and 100 hz. J Phys Ther Sci 2014;26:1945-8.  Back to cited text no. 57
Fuentes J, Armijo-Olivo S, Funabashi M, Miciak M, Dick B, Warren S, et al. Enhanced therapeutic alliance modulates pain intensity and muscle pain sensitivity in patients with chronic low back pain: An experimental controlled study. Phys Ther 2014;94:477-89.  Back to cited text no. 58
Franco KM, Franco YD, Oliveira NB, Miyamoto GC, Santos MO, Liebano RE, et al. Is interferential current before Pilates exercises more effective than placebo in patients with chronic nonspecific low back pain? A Randomized Controlled Trial. Arch Phys Med Rehabil 2017;98:320-8.  Back to cited text no. 59
Corrêa JB, Costa LO, Oliveira NT, Lima WP, Sluka KA, Liebano RE. Effects of the carrier frequency of interferential current on pain modulation and central hypersensitivity in people with chronic nonspecific low back pain: A randomized placebo-controlled trial. Eur J Pain 2016;20:1653-66.  Back to cited text no. 60
Almeida N, Paladini LH, Korelo RG, Liebano RE, de Macedo AC. Immediate effects of the combination of interferential therapy parameters on chronic low back pain: A randomized controlled trial. Pain Pract 2020;20:615-25.  Back to cited text no. 61
Singh A, Raghav S. Effect of interferential therapy along with McKenzie extension bias exercises on pain, disability and spinal extensors muscles strength among the patients with chronic low back pain. Indian J Public Health Res Dev 2020;11:155-61.  Back to cited text no. 62
Nazligul T, Akpinar P, Aktas I, Unlu Ozkan F, Cagliyan Hartevioglu H. The effect of interferential current therapy on patients with subacromial impingement syndrome: A randomized, double-blind, sham-controlled study. Eur J Phys Rehabil Med 2018;54:351-7.  Back to cited text no. 63
Cheing GL, So EM, Chao CY. Effectiveness of electroacupuncture and interferential eloctrotherapy in the management of frozen shoulder. J Rehabil Med 2008;40:166-70.  Back to cited text no. 64
Gaba E, Sethi J, Bhardwaj M. Effect of interferential therapy over ultrasound therapy with common protocol of manual therapy in grade-II frozen shoulder. J Exercise Sci Physiother 2020;16:23-31.  Back to cited text no. 65
Taskaynatan MA, Ozgul A, Ozdemir A, Tan AK, Kalyon TA. Effects of steroid iontophoresis and electrotherapy on bicipital tendonitis. J Musculoskeletal Pain 2007;15:4, 47-54.  Back to cited text no. 66
Koca I, Boyaci A, Tutoglu A, Ucar M, Kocaturk O. Assessment of the effectiveness of interferential current therapy and TENS in the management of carpal tunnel syndrome: A randomized controlled study. Rheumatol Int 2014;34:1639-45.  Back to cited text no. 67
Shahrokhi A, Ghorbani A, Aminianfar A. Impact of interferential current on recovery of pressure ulcers grade 1 and 2. Iran J Nurs Midwifery Res 2014;19:S91-6.  Back to cited text no. 68
Suh H, Petrofsky J, Fish A, Hernandez V, Mendoza E, Collins K, et al. A new electrode design to improve outcomes in the treatment of chronic non-healing wounds in diabetes. Diabetes Technol Ther 2009;11:315-22.  Back to cited text no. 69
Ud-Din S, Sebastian A, Giddings P, Colthurst J, Whiteside S, Morris J, et al. Angiogenesis is induced and wound size is reduced by electrical stimulation in an acute wound healing model in human skin. PLoS One 2015;10:e0124502.  Back to cited text no. 70
Ud-Din S, Bayat A. Electrical stimulation and cutaneous wound healing: A review of clinical evidence. Healthcare (Basel) 2014;2:445-67.  Back to cited text no. 71
Rocha CS, Lanferdini FJ, Kolberg C, Silva MF, Vaz MA, Partata WA, et al. Interferential therapy effect on mechanical pain threshold and isometric torque after delayed onset muscle soreness induction in human hamstrings. J Sports Sci 2012;30:733-42.  Back to cited text no. 72
Anggiat L. Sports rehabilitation phases: A literature review. Int J Med Exerc Sci 2021;7:1096-103.  Back to cited text no. 73
Dhillon H, Dhillon S, Dhillon MS. Current concepts in sports injury rehabilitation. Indian J Orthop 2017;51:529-36.  Back to cited text no. 74
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Hutson JM, Dughetti L, Stathopoulos L, Southwell BR. Transabdominal electrical stimulation (TES) for the treatment of slow-transit constipation (STC). Pediatr Surg Int 2015;31:445-51.  Back to cited text no. 75
Demirtürk F, Akbayrak T, Karakaya IC, Yüksel I, Kirdi N, Demirtürk F, et al. Interferential current versus biofeedback results in urinary stress incontinence. Swiss Med Wkly 2008;138:317-21.  Back to cited text no. 76
Maeda K, Koga T, Akagi J. Interferential current sensory stimulation, through the neck skin, improves airway defense and oral nutrition intake in patients with dysphagia: A double-blind randomized controlled trial. Clin Interv Aging 2017;12:1879-86.  Back to cited text no. 77
Hasegawa Y, Sugahara K, Sano S, Sakuramoto A, Kishimoto H, Oku Y. Enhanced salivary secretion by interferential current stimulation in patients with dry mouth: A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121:481-9.  Back to cited text no. 78
Abhishek P. Mahalle, and Dr. Rashmi Walke. Interferential Therapy and strengthening exercises in management of knee osteoarthritis. J Pharmaceutical Negative Results 2022;13:2856-9.  Back to cited text no. 79
Sanjeev S, Ronika A, Razik A. Comparison of the effect of high voltage pulsed current v/s interferential therapy on pain and womac in patients with knee osteoarthritis. Indian J Physiotherapy and Occupational Therapy - An Int J 2019;13:112.  Back to cited text no. 80
Albornoz-Cabello M, Barrios-Quinta CJ, Espejo-Antúnez L, Escobio-Prieto I, Casuso-Holgado MJ, Heredia-Rizo AM. Immediate clinical benefits of combining therapeutic exercise and interferential therapy in adults with chronic neck pain: A randomized controlled trial. Eur J Phys Rehabil Med 2021;57:767-74.  Back to cited text no. 81
Satter EK. Third-degree burns incurred as a result of interferential current therapy. Am J Dermatopathol 2008;30:281-3.  Back to cited text no. 82
ten Duis HJ. Acute electrical burns. Semin Neurol 1995;15:381-6.  Back to cited text no. 83
Keramat KU, Gaughran A. An unusual effect of interferential therapy. BMJ Case Rep 2012;2012:bcr2012007648.  Back to cited text no. 84


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