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Year : 2015  |  Volume : 15  |  Issue : 2  |  Page : 199-203

Correlation of electrocardiographic and lipid profile changes in newly diagnosed hypothyroid subjects

1 Department of Physiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
2 Department of Community Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
3 Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, West Bengal, India

Correspondence Address:
Arunima Chaudhuri
Krishnasayar South, Borehat, Burdwan - 713 102, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-6308.156375

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Background: Thyroid dysfunction has a great impact on lipid profile and other cardiovascular risk factors. Aims: This study was conducted to assess the association between electrocardiography (ECG) changes and lipid profile in newly diagnosed hypothyroid patients in a rural population of eastern India. Materials and Methods: This cross-sectional pilot project was conducted in a tertiary care hospital in a time span of 1-year on hundred newly diagnosed hypothyroid patients. Fasting blood samples were drawn for assessment of lipid profile followed by Anthropometric measurements. Basal heart rate and blood pressure were recorded, followed by ECG. Results: A total of 85 subjects were female and rest 15 were male. Eleven (73.33%) male hypothyroid patient and 41 (48.24%) female hypothyroid patient had thyroid-stimulating hormone (TSH) level >10. Four (26.67%) male hypothyroid patients and 44 (51.76%) female hypothyroid patients had TSH level ≤10. Fifty-seven hypothyroid patients showed cholesterol level ≤200. Eight (53.33%) male hypothyroid patients and 43 (50.89%) female hypothyroid patient had triglyceride level ≤150 mg/dl. Among 100 hypothyroid patients, 13 (15.29%) female hypothyroid patient had sinus bradycardia and 9 (10.59%) had poor progression of R wave. Two (13.33%) male hypothyroid patient and 19 (22.35%) female hypothyroid patients showed low voltage ECG. QRS complex of ECG showed statistically significant relationship (P < 0.000) with TSH level. All parameters of lipid profile except high-density lipoprotein had a significant negative co-relation with QRS complex. Conclusions: The present study shows that there are exit significant changes in ECG with increased TSH levels and dyslipidemia. Early diagnosis of these changes may help in proper management of these patients.

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